Genetic testing for breast cancer

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Thinking about cancer or dealing with cancer risk can be scary or overwhelming, but we believe that receiving information and resources is comforting, empowering, and lifesaving. Genetic testing has improved since then and new tests can find mutations that were previously missed by older tests. The following gene mutations have been linked with an increased risk for breast cancer.

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Abnormal PALB2 genes are suspected to raise the risk of ovarian cancer, but larger studies need to confirm that risk. Men with these mutations have an increased risk of breast cancer, especially if the BRCA2 gene is affected, and possibly of prostate cancer. Many inherited cases of breast cancer have been associated with mutations in these three genes.

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Who will be offered genetic testing? How is the test done? Getting your predictive genetic test results 4.

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Breast cancer is the most common type of cancer in women in British Columbia. Breast cancer can occur in men as well, but it is not as common. Tests and treatments for breast cancer vary from person to person, and are based on individual circumstances. Certain factors such as your age, family history, or a previous breast cancer diagnosis may increase your risk of developing breast cancer.

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When either of these genes is mutated, or altered, such that its protein product is not made or does not function correctly, DNA damage may not be repaired properly. As a result, cells are more likely to develop additional genetic alterations that can lead to cancer. People who have inherited mutations in BRCA1 and BRCA2 tend to develop breast and ovarian cancers at younger ages than people who do not have these mutations.

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After a routine mammogram in revealed a tumor in her right breast, Wendy Mayer was diagnosed with invasive lobular carcinoma. Fortunately, it had not spread. But her mother, her grandmother, and a cousin had all had breast cancer, so on the advice of her doctors, Mayer underwent genetic testing.

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April 9,by NCI Staff. Many women diagnosed with ovarian and breast cancers are not receiving tests for inherited genetic mutations, according to a new study. Tests for inherited genetic mutations can provide women diagnosed with ovarian or breast cancer with important information that can have implications for family members and potentially guide treatment decisions and longer-term screening for second cancers.

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Back to Health A to Z. BRCA genes are not the only cancer risk genes. Researchers recently identified more than new gene variants associated with an increased risk of breast, prostate and ovarian cancer.

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Genetic testing gives people the chance to learn if their breast cancer or family history of breast cancer is due to an inherited gene mutation. This section provides information on genetic counseling and testing for gene mutations that increase breast cancer risk. It also has information on inherited gene mutations and other related topics, such as the benefits and risks of testing, direct-to-consumer genetic testing and testing for multiple high-risk gene mutations panel testing.

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The choice to have genetic counseling and proceed with genetic testing is one to be taken seriously and with some caution. Though it can sound simple to be tested, there are many things to consider before making this decision. Our physicians and nurses will help guide you through the entire process so you understand the pros and cons of genetic testing. If you or your family is interested, you should go to a facility that has many years of experience with genetic counseling and testing for breast cancer.

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